What is decanoic acid

Due to their ability to be absorbed rapidly by the body, medium-chain triglycerides have found use in the treatment of a variety of malabsorption ailments. MCT supplementation with a low-fat diet has been described as the cornerstone of treatment for Waldmann disease . [14] MCTs are an ingredient in some specialised parenteral nutritional emulsions in some countries. [15] [16] Studies have also shown promising results for epilepsy through the use of ketogenic dieting . [17] [18] Select studies have shown promising results for neurodegenerative disorders (. Alzheimer's and Parkinson's diseases ) [19] but clinical effectiveness is not yet established.

Decanoic acid acts as a non-competitive AMPA receptor antagonist at therapeutically relevant concentrations, in a voltage- and subunit-dependent manner, and this is sufficient to explain its antiseizure effects. [12] This direct inhibition of excitatory neurotransmission by decanoic acid in the brain contributes to the anticonvulsant effect of the MCT ketogenic diet . [12] Decanoic acid and the AMPA receptor antagonist drug perampanel act at separate sites on the AMPA receptor, and so it is possible that they have a cooperative effect at the AMPA receptor, suggesting that perampanel and the ketogenic diet could be synergistic. [12]

What is decanoic acid

what is decanoic acid

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