Many bodybuilders combine drostanolone with other AAS. [ citation needed ] Drostanolone itself is only weakly anabolic, which is why it is not used alone during bulking cycles. [ citation needed ] However, when combined with other anabolic steroids, drostanolone may enhance their effects. Also, drostanolone binds sex hormone-binding globulin (SHBG) which usually will bind a portion of free sex hormones and steroids, like testosterone, and inactivate them. When drostanolone binds to SHBG, the level of unbound SHBG drops, lowering the chance of it binding to other steroids, which increases their bioavailablilty.